Nephrotic syndrome during treatment with interferon.

Adverse reactions develop in roughly one third of patients treated with gold, the proportion varying from 5",, to 80O, in several reported series.' Eosinophilia occurs in roughly 5O, of patients and has been directly correlated with the development of gold toxicity.2 Vasomotor reactions to gold are not uncommon, but whether they indicate the development of more serious gold toxicity is unknown. Neurological complications, including peripheral neuropathy, myokymia, and a syndrome like the Guillain-Barre syndrome,3 have received little attention even in major textbooks of rheumatology.4 Encephalopathy has been reported: McAuley et al described a patient who recovered fully one month after treatment with gold was stopped.0 The severity of the illness in our patient, with residual neurological deficit nearly five months afterwards, shows the serious side effects that may occur during chrysotherapy.